abstract：:Elderly healthy individuals have a reduced exercise tolerance and a decreased left ventricle inotropic reserve related to increased vascular afterload, arterial-ventricular load mismatching, physical deconditioning and impaired autonomic regulation (the so called "β-adrenergic desensitization"). Adrenergic responsiven...

journal_title：Frontiers in physiology

authors： Ferrara N,Komici K,Corbi G,Pagano G,Furgi G,Rengo C,Femminella GD,Leosco D,Bonaduce D

更新日期：2014-01-09 00:00:00

abstract：:Phosphofructokinase deficiency is a very rare autosomal recessive disorder, which belongs to group of rare inborn errors of metabolism called glycogen storage disease. Here we report on a new mutation in the phosphofructokinase (PFK) gene PFKM identified in a 65-years-old woman who suffered from lifelong intermittent ...

journal_title：Frontiers in physiology

authors： Vives-Corrons JL,Koralkova P,Grau JM,Mañú Pereira Mdel M,Van Wijk R

更新日期：2013-12-30 00:00:00

abstract：:The aim of this perspective article is to share with the community of ion channel scientists our thoughts and expectations regarding the increasing role that computational tools will play in the future of our field. The opinions and comments detailed here are the result of a 3-day long international exploratory worksh...

journal_title：Frontiers in physiology

authors： Abriel H,de Lange E,Kucera JP,Loussouarn G,Tarek M

更新日期：2013-12-26 00:00:00

abstract：:Genome-wide association studies and physiological investigations have linked alterations in acid-base transporters to hypertension. Accordingly, Na(+)-coupled HCO(-) 3-transporters, Na(+)/H(+)-exchangers, and anion-exchangers have emerged as putative mechanistic components in blood pressure disturbances. Even though h...

journal_title：Frontiers in physiology

authors： Boedtkjer E,Aalkjaer C

更新日期：2013-12-24 00:00:00

abstract：:Spinal muscular atrophy (SMA), amyotrophic lateral sclerosis (ALS), and spinal-bulbar muscular atrophy (SBMA) are devastating diseases characterized by the degeneration of motor neurons. Although the molecular causes underlying these diseases differ, recent findings have highlighted the contribution of intrinsic skele...

journal_title：Frontiers in physiology

authors： Boyer JG,Ferrier A,Kothary R

更新日期：2013-12-18 00:00:00

abstract：:The appearance of oxygen in the terrestrial atmosphere represented an important selective pressure for ancestral living organisms and contributed toward setting up the pace of evolutionary changes in structural and functional systems. The evolution of using oxygen for efficient energy production served as a driving fo...

journal_title：Frontiers in physiology

authors： Naudí A,Jové M,Ayala V,Portero-Otín M,Barja G,Pamplona R

更新日期：2013-12-17 00:00:00

abstract：:Pancreatic cancer shows a characteristic tissue structure called desmoplasia, which consists of dense fibrotic stroma surrounding cancer cells. Interactions between pancreatic cancer cells and stromal cells promote invasive growth of cancer cells and establish a specific microenvironment such as hypoxia which further ...

journal_title：Frontiers in physiology

authors： Hamada S,Masamune A,Shimosegawa T

更新日期：2013-11-01 00:00:00

abstract：:Pluripotency in human embryonic stem cells (hESCs) and induced pluripotent stem cells (iPSCs) is regulated by three transcription factors-OCT3/4, SOX2, and NANOG. To fully exploit the therapeutic potential of these cells it is essential to have a good mechanistic understanding of the maintenance of self-renewal and pl...

journal_title：Frontiers in physiology

authors： Peterson H,Abu Dawud R,Garg A,Wang Y,Vilo J,Xenarios I,Adjaye J

更新日期：2013-10-28 00:00:00

abstract：:Carbon monoxide (CO) that is produced in a number of different mammalian tissues is now known to have significant effects on the cardiovascular system. These include: (i) vasodilation, (ii) changes in heart rate and strength of contractions, and (iii) modulation of autonomic nervous system input to both the primary pa...

journal_title：Frontiers in physiology

authors： Trenor B,Cardona K,Saiz J,Rajamani S,Belardinelli L,Giles WR

更新日期：2013-10-17 00:00:00

abstract：:Local purinergic signals modulate renal tubular transport. Acute activation of renal epithelial P2 receptors causes inhibition of epithelial transport and thus, should favor increased water and salt excretion by the kidney. So far only a few studies have addressed the effects of extracellular nucleotides on ion transp...

journal_title：Frontiers in physiology

authors： Marques RD,Praetorius HA,Leipziger J

更新日期：2013-10-09 00:00:00

abstract：:Autophagy, or cellular self-eating, is a tightly regulated cellular pathway the main purpose of which is lysosomal degradation and subsequent recycling of cytoplasmic material to maintain normal cellular homeostasis. Defects in autophagy are linked to a variety of pathological states, including cancer. Cancer is the d...

journal_title：Frontiers in physiology

authors： Kondratskyi A,Yassine M,Kondratska K,Skryma R,Slomianny C,Prevarskaya N

更新日期：2013-10-02 00:00:00

abstract：:Skeletal muscle makes up approximately 40% of the total body mass, providing structural support and enabling the body to maintain posture, to control motor movements and to store energy. It therefore plays a vital role in whole body metabolism. Skeletal muscle displays remarkable plasticity and is able to alter its si...

journal_title：Frontiers in physiology

authors： Zacharewicz E,Lamon S,Russell AP

更新日期：2013-09-30 00:00:00

abstract：:Nutrition, via the insulin/insulin-like growth factor (IIS)/Target of Rapamycin (TOR) signaling pathway, can provide a strong molding force for determining animal size and shape. For instance, nutrition induces a disproportionate increase in the size of male horns in dung and rhinoceros beetles, or mandibles in stagho...

journal_title：Frontiers in physiology

authors： Koyama T,Mendes CC,Mirth CK

更新日期：2013-09-26 00:00:00

abstract：:Recent concerns over the impact of antidepressant medications, including the selective serotonin reuptake inhibitors (SSRIs), on cardiovascular function highlight the importance of research on the moderating effects of specific lifestyle factors such as physical activity. Studies in affective neuroscience have demonst...

journal_title：Frontiers in physiology

authors： Hanson CS,Outhred T,Brunoni AR,Malhi GS,Kemp AH

更新日期：2013-09-24 00:00:00

abstract：:In this paper we develop a novel mathematical model of the insulin-TOR-MAPK signaling network that controls growth. Most data on the properties of the insulin and MAPK signaling networks are static and the responses to experimental interventions, such as knockouts, overexpression, and hormonal input are typically repo...

journal_title：Frontiers in physiology

authors： Nijhout HF,Callier V

更新日期：2013-09-12 00:00:00

abstract：:In Bombyx mori, polar body nuclei are observed until 9 h after egg lying, however, the fate of polar body nuclei remains unclear. To examine the fate of polar body nuclei, we employed a mutation of serosal cell pigmentation, pink-eyed white egg (pe). The heterozygous pe/+ (pe) females produced black serosal cells in w...

journal_title：Frontiers in physiology

authors： Sakai H,Yokoyama T,Abe H,Fujii T,Suzuki MG

更新日期：2013-09-03 00:00:00

abstract：:Trace conditioning is a form of associative learning that can be induced by presenting a conditioned stimulus (CS) and an unconditioned stimulus (US) following each other, but separated by a temporal gap. This gap distinguishes trace conditioning from classical delay conditioning, where the CS and US overlap. To bridg...

journal_title：Frontiers in physiology

authors： Dylla KV,Galili DS,Szyszka P,Lüdke A

更新日期：2013-08-23 00:00:00

abstract：INTRODUCTION:Near-infrared (NIR) imaging has emerged as a novel imaging modality for assessing lymphatic function in vivo. While the technique has provided quantitative data previously unavailable, questions remain in regards to the spatiotemporal capabilities of the approach. We address three of the more important iss...

journal_title：Frontiers in physiology

authors： Weiler M,Dixon JB

更新日期：2013-08-15 00:00:00

abstract：:Defects in mitochondrial ribosomal proteins (MRPs) cause various diseases in humans. Because of the essential role of MRPs in synthesizing the essential subunits of oxidative phosphorylation (OXPHOS) complexes, identifying all of the protein components involved in the mitochondrial translational machinery is critical....

journal_title：Frontiers in physiology

authors： Koc EC,Cimen H,Kumcuoglu B,Abu N,Akpinar G,Haque ME,Spremulli LL,Koc H

更新日期：2013-07-30 00:00:00

abstract：:Coral reef communities are undergoing marked declines due to a variety of stressors including disease. The sea fan coral, Gorgonia ventalina, is a tractable study system to investigate mechanisms of immunity to a naturally occurring pathogen. Functional studies in Gorgonia ventalina immunity indicate that several key ...

journal_title：Frontiers in physiology

authors： Burge CA,Mouchka ME,Harvell CD,Roberts S

更新日期：2013-07-25 00:00:00

abstract：:A rich chapter in the history of insect endocrinology has focused on hormonal control of diapause, especially the major roles played by juvenile hormones (JHs), ecdysteroids, and the neuropeptides that govern JH and ecdysteroid synthesis. More recently, experiments with adult diapause in Drosophila melanogaster and th...

journal_title：Frontiers in physiology

authors： Sim C,Denlinger DL

更新日期：2013-07-22 00:00:00

abstract：:During embryonic development, multipotent endodermal cells differentiate to form the pancreas. Islet cell clusters arising from the pancreatic bud form the acini tissue and exocrine ducts whilst pancreatic islets form around the edges of the clusters. The successive steps of islet differentiation are controlled by a c...

journal_title：Frontiers in physiology

authors： O'Dowd JF,Stocker CJ

更新日期：2013-07-18 00:00:00

abstract：:Throughout evolution the foraging and echolocation behaviors as well as the motor systems of bats have been adapted to the tasks they have to perform while searching and acquiring food. When bats exploit the same class of environmental resources in a similar way, they perform comparable tasks and thus share similar ad...

journal_title：Frontiers in physiology

authors： Denzinger A,Schnitzler HU

更新日期：2013-07-03 00:00:00

abstract：:Bioenergetic profiling of cancer cells is of great potential because it can bring forward new and effective therapeutic strategies along with early diagnosis. Metabolic Control Analysis (MCA) is a methodology that enables quantification of the flux control exerted by different enzymatic steps in a metabolic network th...

journal_title：Frontiers in physiology

authors： Kaambre T,Chekulayev V,Shevchuk I,Tepp K,Timohhina N,Varikmaa M,Bagur R,Klepinin A,Anmann T,Koit A,Kaldma A,Guzun R,Valvere V,Saks V

更新日期：2013-06-28 00:00:00

abstract：:This study aimed to test the hypothesis that branchial osmoregulatory acclimation involved increased apoptosis and replacement of mitochdonrion-rich cells (MRCs) in the climbing perch, Anabas testudineus, during a progressive acclimation from freshwater to seawater. A significant increase in branchial caspase-3/-7 act...

journal_title：Frontiers in physiology

authors： Ching B,Chen XL,Yong JH,Wilson JM,Hiong KC,Sim EW,Wong WP,Lam SH,Chew SF,Ip YK

更新日期：2013-06-07 00:00:00

abstract：:Finding an optimum for the cycling performance is not a trivial matter, since the literature shows the presence of many controversial aspects. In order to quantify different levels of performance, several indexes have been defined and used in many studies, reflecting variations in physiological and biomechanical facto...

journal_title：Frontiers in physiology

authors： Castronovo AM,Conforto S,Schmid M,Bibbo D,D'Alessio T

更新日期：2013-05-21 00:00:00

abstract：:We have been able to reduce substantially patient pool heterogeneity by identifying phenotypic markers that allow the researcher to stratify chronic fatigue syndrome (CFS) patients into subgroups. To date, we have shown that stratifying based on the presence or absence of comorbid psychiatric diagnosis leads to a grou...

journal_title：Frontiers in physiology

authors： Natelson BH

更新日期：2013-05-20 00:00:00

abstract：:Mitochondrial redox imbalance has been implicated in mechanisms of aging, various degenerative diseases and drug-induced toxicity. Statins are safe and well-tolerated therapeutic drugs that occasionally induce myotoxicity such as myopathy and rhabdomyolysis. Previous studies indicate that myotoxicity caused by statins...

journal_title：Frontiers in physiology

authors： La Guardia PG,Alberici LC,Ravagnani FG,Catharino RR,Vercesi AE

更新日期：2013-05-15 00:00:00

abstract：UNLABELLED:Oxycodone (OXY) is one of the most commonly abused opiates during pregnancy. Perinatal opiate exposure (POE) is associated with neurobehavioral and hormone changes. Little is known about the effects of perinatal OXY on the cardiovascular (CV) responses to stress. OBJECTIVES:to determine the effects of POE o...

journal_title：Frontiers in physiology

authors： Sithisarn T,Bada HS,Charnigo RJ,Legan SJ,Randall DC

更新日期：2013-04-24 00:00:00

abstract：:The harbor porpoise is one of the smallest and most widely spread of all toothed whales. They are found abundantly in coastal waters all around the northern hemisphere. They are among the 11 species known to use high frequency sonar of relative narrow bandwidth. Their narrow biosonar beam helps isolate echoes from pre...

journal_title：Frontiers in physiology

authors： Miller LA,Wahlberg M

更新日期：2013-04-15 00:00:00

abstract：:A water surface acts not only as an optic mirror but also as an acoustic mirror. Echolocation calls emitted by bats at low heights above water are reflected away from the bat, and hence the background clutter is reduced. Moreover, targets on the surface create an enhanced echo. Here, we formally quantified the effect ...

journal_title：Frontiers in physiology

authors： Zsebok S,Kroll F,Heinrich M,Genzel D,Siemers BM,Wiegrebe L

更新日期：2013-04-05 00:00:00

abstract：UNLABELLED:Limitations of current methods: Normalization of resting energy expenditure (REE) for body composition using the 2-compartment model fat mass (FM), and fat-free mass (FFM) has inherent limitations for the interpretation of REE and may lead to erroneous conclusions when comparing people with a wide range of a...

journal_title：Frontiers in physiology

authors： Bosy-Westphal A,Braun W,Schautz B,Müller MJ

更新日期：2013-03-25 00:00:00

abstract：:Collective behavior in the forest tent caterpillar (Malacosoma disstria) meets the thermal constraints of being an early spring folivore, but introduces other constraints in food choice. These are minimized by state-dependent, inter-individual, and ontogenetic variations in responses to social cues. Forest tent caterp...

journal_title：Frontiers in physiology

authors： Despland E

更新日期：2013-03-22 00:00:00

abstract：:The mouse is one of the most important model organisms for understanding human genetic function and disease. This includes characterization of the factors that influence energy expenditure and dysregulation of energy balance leading to obesity and its sequelae. Measuring energy metabolism in the mouse presents a chall...

journal_title：Frontiers in physiology

authors： Speakman JR

更新日期：2013-03-14 00:00:00

abstract：:We describe our development of the diffusion tensor imaging modality for the bovine ocular lens. Diffusion gradients were added to a spin-echo pulse sequence and the relevant parameters of the sequence were refined to achieve good diffusion weighting in the lens tissue, which demonstrated heterogeneous regions of diff...

journal_title：Frontiers in physiology

authors： Vaghefi E,Donaldson PJ

更新日期：2013-03-01 00:00:00

abstract：:Hepatocellular carcinomas (HCCs) have different etiology and heterogenic genomic alterations lead to high complexity. The molecular features of HCC have largely been studied by gene expression and proteome profiling focusing on the correlations between the expression of specific markers and clinical data. Integration ...

journal_title：Frontiers in physiology

authors： D'Alessandro LA,Meyer R,Klingmüller U

更新日期：2013-02-25 00:00:00

abstract：:Whether neurally-mediated vasodilatation may contribute to exercise hyperemia has not been completely understood. Bülbring and Burn (1935) found for the first time the existence of sympathetic cholinergic nerve to skeletal muscle contributing to vasodilatation in animals. Blair et al. (1959) reported that atropine-sen...

journal_title：Frontiers in physiology

authors： Matsukawa K,Ishii K,Liang N,Endo K

更新日期：2013-02-15 00:00:00

abstract：:Arboviruses are emerging/reemerging infectious agents worldwide. The factors within this scenario include vector and host population fluctuations, climatic changes, anthropogenic activities that disturb ecosystems, an increase in international flights, human mobility, and genetic mutations that allow spill-over phenom...

journal_title：Frontiers in physiology

authors： Diaz LA,Flores FS,Quaglia A,Contigiani MS

更新日期：2013-01-11 00:00:00

abstract：:The paraventricular nucleus (PVN) of the hypothalamus is an important site for autonomic and neuroendocrine regulation. Experiments in anesthetized animals and in vitro indicate an interaction among gamma-aminobutyric acid (GABA), nitric oxide (NO), and glutamate in the PVN. The cardiovascular role of the PVN and inte...

journal_title：Frontiers in physiology

authors： Martins-Pinge MC,Mueller PJ,Foley CM,Heesch CM,Hasser EM

更新日期：2013-01-09 00:00:00

abstract：:Muscle fatigue is the decline in performance of muscles observed during periods of intense activity. ATP consumption exceeds production during intense activity and there are multiple changes in intracellular metabolites which may contribute to the changes in crossbridge activity. It is also well-established that a red...

journal_title：Frontiers in physiology

authors： Allen DG,Trajanovska S

更新日期：2012-12-11 00:00:00